Rabies vaccine, killed virus.
Defensor 3. Pfizer Animal Health. Rabies Vaccine. Killed Virus. For use in dogs, cats, cattle, and sheep only. PRODUCT DESCRIPTION: Defensor 3 is for vaccination of healthy dogs, cats, cattle and sheep 3 months of age or older as an aid in preventing rabies. The vaccine is prepared from cell- culture- grown, chemically inactivated rabies virus. The seed virus is a highly immunogenic, fixed strain of rabies virus which originated from Louis Pasteur's original isolate in 1.
The inactivated virus is formulated with a highly purified adjuvant and is packaged in liquid form. DISEASE DESCRIPTION: Rabies is a worldwide, high mortality disease affecting mammalian species. Wild animals are common vectors of the disease and the major source of transmission to humans and domestic animals. Domestic animals are the major source of exposure for humans. Since 1. 98. 0, the most commonly reported rabid domestic animals have been cats, cattle, and dogs. In 2. 00. 4, a total of 6,8.
States consider controlling rabies vaccination. States consider controlling rabies vaccination. 1 and Defensor 3 vaccines made by Pfizer. Rabies Vaccines Licensed and Marketed in the U.S., 2008. Rabies Vaccine Supply Situation; August 29. The following must be filled in on the rabies certificate: 1. Serial Number: Fill in the vaccine serial number which is on each vaccine vial or tanker. An introduction to IMRAB 3 and other IMRAB products for preventing rabies in. The Benefits of IMRAB.
Center for Disease Control by 4. Puerto Rico. 1 Susceptibility to rabies varies according to pet species. Rabies is not a treatable disease and suspect pets are usually quarantined until a clinical diagnosis is made, at which time they are destroyed. The route of infection can be oral, respiratory, or parenteral. Following infection, a paralytic syndrome ensues, emerging as either the .
DEFENSOR 1 is for vaccination of healthy dogs and cats 3 months of age or older as an aid in preventing rabies. Our broad portfolio of vaccines and pharmaceutical medicines help maintain and improve animal health. Defensor Rabies vaccines contain an inactivated rabies virus from an. Use of an established cell line yields a vaccine of consistent potency from serial to.
Respiratory failure is the immediate cause of death. SAFETY AND EFFICACY: Because Defensor 3 is produced on an established cell line, it has safety advantages over inactivated brain- origin rabies vaccines. Tissue- origin vaccines contain extraneous protein in addition to rabies antigen that can lead to autoimmune disease.
The established cell line used in Defensor 3 has been extensively tested for freedom from contaminating agents. In addition, use of an established cell line yields a vaccine of consistent potency from serial to serial. Defensor 3 has proven to be uniformly safe in experimental tests, and no significant adverse reactions were reported in extensive clinical trials of the vaccine. A duration- of- immunity study, conducted in accordance with federal regulation and under U. S. Department of Agriculture direction, demonstrated that a 1- m.
L dose met federal guidelines for protection of dogs and cats against virulent challenge administered 3 years after vaccination. Cattle and sheep were likewise protected 1 year after receiving a 2- m.
L dose of Defensor 3. DIRECTIONS: Dogs and Cats: General Directions: Shake well. Aseptically administer 1 m. L subcutaneously. Dogs may be vaccinated intramuscularly or subcutaneously. Primary Vaccination: Administer a single 1- m.
L dose at 3 months of age or older to healthy dogs and cats. A repeat dose should be administered 1 year later. Revaccination: Subsequent revaccination every 3 years with a single dose is recommended. Cattle and Sheep: General Directions: Shake well. Aseptically administer 2- m. L intramuscularly.
Primary Vaccination: Administer a single 2- m. L dose at 3 months of age or older to healthy cattle and sheep. A repeat dose should be administered 1 year later. Revaccination: Annual revaccination with a single dose is recommended. PRECAUTIONS: Store at 2. Prolonged exposure to higher temperatures may adversely affect potency.
Do not freeze. Use entire contents when first opened. Sterilized syringes and needles should be used to administer this vaccine. Do not vaccinate within 2. Contains gentamicin as preservative.
As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy. This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions. REFERENCES: 1. Krebs JW, Mandel EJ, Rupprecht CE, Swerdlow DL: Rabies sruveillance in the United States during 2.
JAVMA 2. 27(1. 2): 1. Technical inquiries should be directed to Pfizer Animal Health Veterinary Services, (8. USA), (8. 00) 4. 61- 0. Canada). For veterinary use only. U. S. Veterinary License No. Pfizer Animal Health, Exton, PA 1.